Hoffenheim – Olympique Lyonnais Preview – Can Hoffenheim finally get off the mark?
Our Hoffenheim vs Olympique Lyonnais betting tips start from an awkward fact: the home side have no points in the Europa League league phase, yet we still lean towards them. Kick-off is on 22 October 2026 at 19:00 GMT.
- 22/10/2026
The lean makes sense once you look at the week. Hoffenheim ended a losing run with a 2-1 win at bottom club Gladbach on Sunday, a result that should loosen the shoulders. Lyon won the same day, 2-1 against Nice, and went top of Ligue 1, but they did it with ten men after Nakamura was sent off in the second half. Whether that red card carries a ban for this game is not confirmed.
Lyon have also won every league-phase match so far. They beat Crystal Palace 3-2 last week, a game that told you plenty about how they like to play: quick, direct, and a bit loose at the back.
Hoffenheim – Olympique Lyonnais Betting Tips
Betting Tip: Hoffenheim to win
Hoffenheim have nothing in the table yet and need this one badly, at home, with a fresh win behind them. Lyon arrive without Tagliafico, Ouédraogo and Openda, and a side with ten men for the last stretch on Sunday may not be at its freshest. Hoffenheim are a slight edge rather than a banker, but the home side’s need and the visitors’ absences tip it for us.
Betting Tip: Over 3.5 goals
- Hoffenheim have seen four or more goals in three of their last five matches
- Olympique Lyonnais have scored 12 goals in their last five matches
Hoffenheim’s last two home games both ended 2-3, and Lyon’s most recent Europa League outing was a 3-2 win. Neither side is built to keep a clean sheet right now, and both have attackers who will get chances. This is the higher line, so it takes a proper shootout, but everything about these two says that is how it goes.
If you like both picks, check the latest match odds on the sportsbook and see how they price up before kick-off. Squad news can shift the picture, so look again closer to the game.
Two leaky sides and a short turnaround
Hoffenheim have conceded freely at home lately. Their last two games at their own ground both finished 2-3, against Hamburg in the Bundesliga and Besiktas in this competition. Those are not the numbers of a side that shuts games down.
Both teams are also missing bodies. Hoffenheim are reported to be without De Cat, Hajdari and Wimmer, while Lyon are without Tagliafico, Ouédraogo and Openda. Losing Tagliafico and Openda takes some of the polish from the visitors at both ends. There is also a Leverkusen visit to Hoffenheim three days later, which may nudge rotation, though the lineup is not known yet.
Our preview of Hoffenheim’s last Europa League home game covers how that 2-3 defeat unfolded, and it is worth a read before you back anything here. For Lyon’s own recent form in the competition, see our look at their win over Crystal Palace.
Frequently asked questions
When does Hoffenheim vs Lyon kick off?
The match is on 22 October 2026 at 19:00 GMT.
Who is the favourite?
We lean towards Hoffenheim, helped by home advantage and their need for points.
What is our main tip?
Hoffenheim to win, with over 3.5 goals as the companion call.
- 22/10/2026
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